Diffuse Lewy body disease

@article{Lin2019DiffuseLB,
  title={Diffuse Lewy body disease},
  author={Yu Lin and D. Truong},
  journal={Journal of the Neurological Sciences},
  year={2019},
  volume={399},
  pages={144-150}
}
  • Yu Lin, D. Truong
  • Published 2019
  • Medicine
  • Journal of the Neurological Sciences
Diffuse Lewy body disease, also called dementia with Lewy bodies (DLB), is defined as progressive dementia and pathological Lewy bodies distributed in the central and autonomic nervous systems. The clinical features are dementia, cognitive fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD). Confirmatory techniques include dopamine transporter imaging, meta-iodobenzylguanidine (MIBG) myocardial scintigraphy, and polysomnography. The pathology finding in DLB… Expand
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References

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Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe.
TLDR
Cognitive fluctuations and/or visual hallucinations were not good predictors of DLB in pathologically proven patients, although the absence of these features early in the disease course was highly predictive of PDD. Expand
Diagnosis and management of dementia with Lewy bodies
TLDR
The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. Expand
Structural and functional imaging study in dementia with Lewy bodies and Parkinson's disease dementia.
TLDR
Evaluated whether DLB and PDD may be labelled under the same disease entity or be considered distinctive pathologies, finding different brain areas are specifically involved in PDD and DLB. Expand
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TLDR
This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD. Expand
Early detection of dementia with Lewy bodies in patients with amnestic mild cognitive impairment using 123I-MIBG cardiac scintigraphy
TLDR
The clinical courses of these patients suggest that (123)I-MIBG cardiac scintigraphy is useful for the detection of DLB in the predementia phase, even before core clinical features appear, as well as supporting the idea that cardiac sympathetic denervation is due to underlying Lewy body disease. Expand
Diagnosis and management of dementia with Lewy bodies
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use forExpand
DLB and PDD boundary issues
TLDR
The authors agreed to endorse “Lewy body disorders” as the umbrella term for PD, PDD, and DLB to promote the continued practical use of these three clinical terms, and to encourage efforts at drug discovery that target the mechanisms of neurodegeneration shared by these disorders of α-synuclein metabolism. Expand
123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies
TLDR
123I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage of dementia with Lewy bodies during this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. Expand
Clinical and Neuropsychological Differences between Mild Parkinson's Disease Dementia and Dementia with Lewy Bodies
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The cognitive profile in PDD differs from that in DLB in the early stage of dementia, with worse performance on tests of attention and executive functions and constructive abilities inDLB compared to PDD patients. Expand
Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy
TLDR
FP-CIT SPECT scans substantially enhanced the accuracy of diagnosis of DLB by comparison with clinical criteria alone, in a series of patients with dementia in whom autopsy confirmation of diagnosis was available. Expand
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