Diffuse Infiltrative Lung Disease Associated with Flecainide

@article{Pesenti2002DiffuseIL,
  title={Diffuse Infiltrative Lung Disease Associated with Flecainide},
  author={Sarah Pesenti and Dominique Lauque and Ghislaine Daste and Vincent Boulay and M. C. Pujazon and Pierre Carles},
  journal={Respiration},
  year={2002},
  volume={69},
  pages={182 - 185}
}
We present two patients who developed subacute diffuse infiltrative lung disease while receiving flecainide for supraventricular arrhythmia. They had bilateral subpleural lung opacities on computed tomography. Bronchoalveolar lavage revealed increased numbers of lymphocytes and eosinophils, and a low CD4/CD8 ratio. Nonspecific interstitial pneumonia was documented by open lung biopsy in patient 1. The outcome was favorable after flecainide withdrawal and prednisone treatment. Drug-induced… 

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