Difficulty interpreting the results of some trials: the case of therapeutic hypothermia after pediatric cardiac arrest

@inproceedings{Vincent2015DifficultyIT,
  title={Difficulty interpreting the results of some trials: the case of therapeutic hypothermia after pediatric cardiac arrest},
  author={Jean-Louis Vincent and Fabio Silvio Taccone},
  booktitle={Critical Care},
  year={2015}
}
Therapeutic hypothermia or targeted temperature management (TTM) is widely used after cardiac arrest (CA) in adult patients and improves survival and neurologic outcome after out-of-hospital CA due to shockable rhythms [1]. However, several issues, including the optimal target temperature, the time to initiate cooling and the most effective duration, remain controversial in this setting [2]. In neonatal hypoxic encephalopathy, randomized controlled trials (RCTs) have shown that cooling comatose… CONTINUE READING
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