Difficulty in determining the association of a single nucleotide polymorphism in the ZNF512B gene with the risk and prognosis of amyotrophic lateral sclerosis.

@article{Tetsuka2017DifficultyID,
  title={Difficulty in determining the association of a single nucleotide polymorphism in the ZNF512B gene with the risk and prognosis of amyotrophic lateral sclerosis.},
  author={Syuichi Tetsuka},
  journal={Rinsho shinkeigaku = Clinical neurology},
  year={2017},
  volume={57 8},
  pages={
          417-424
        }
}
  • S. Tetsuka
  • Published 22 July 2017
  • Biology
  • Rinsho shinkeigaku = Clinical neurology
The advent of next-generation sequencing technology is expected to accelerate the identification of novel genes, and this technology will likely supersede Sanger sequencing. Thus, genome-wide association studies (GWASs) are performed more routinely in an effort to identify disease-susceptibility genes for sporadic amyotrophic lateral sclerosis (ALS). Previously, a Japanese team conducted a large-scale GWAS with 1,305 Japanese ALS patients and discovered a new single nucleotide polymorphism (SNP… 

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Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis
TLDR
The available evidence suggests that the ZNF512B polymorphism rs2275294 is associated with ALS risk, and these results should be validated in large, well-designed studies, especially in non-Asian populations.

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