Difficult asthma in children: an analysis of airway inflammation.

  title={Difficult asthma in children: an analysis of airway inflammation.},
  author={Jacques de Blic and Isabelle Tillie-Leblond and Andr{\'e} Bernard Tonnel and Francis Jaubert and Pierre Scheinmann and Philippe Gosset},
  journal={The Journal of allergy and clinical immunology},
  volume={113 1},
BACKGROUND Difficult asthma in children displays distinct clinical patterns, and its physiopathology remains poorly understood. OBJECTIVE To determine the characteristics of the bronchial inflammatory profile in children with difficult asthma. METHODS We performed endobronchial biopsy and bronchoalveolar lavage in 28 children with persistent bronchial… CONTINUE READING