Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. II. Isolation and physico-chemical characterization.

@article{Wilson1987DifficidinAO,
  title={Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. II. Isolation and physico-chemical characterization.},
  author={Kenneth E. Wilson and J E Flor and Robert E. Schwartz and Henry Joshua and J. Lorrain Smith and Barbara A Pelak and Jerrold M. Liesch and Otto D. Hensens},
  journal={The Journal of antibiotics},
  year={1987},
  volume={40 12},
  pages={1682-91}
}
The isolation of difficidin (1) and oxydifficidin (2) from fermentation broth of Bacillus subtilis ATCC 39320 and the physico-chemical characterization of these labile antibiotics are described. The structures of the compounds represent a new class of antibiotics, characterized as highly unsaturated 22-membered macrolide phosphates. Difficidin and oxydifficidin undergo reversible thermal isomerization to 3 and 4 respectively. Biological evaluation of the isomers is presented. 
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