Differing temporal roles of Ca2+ and cAMP in nicotine-elicited elevation of tyrosine hydroxylase mRNA.

@article{Gueorguiev1999DifferingTR,
  title={Differing temporal roles of Ca2+ and cAMP in nicotine-elicited elevation of tyrosine hydroxylase mRNA.},
  author={Volodia D Gueorguiev and Richard J. Zeman and Bhargava Hiremagalur and Ana Cristina Leite Menezes and Esther L. Sabban},
  journal={The American journal of physiology},
  year={1999},
  volume={276 1 Pt 1},
  pages={C54-65}
}
The involvement of cAMP- and Ca2+-mediated pathways in the activation of tyrosine hydroxylase (TH) gene expression by nicotine was examined in PC-12 cells. Extracellular Ca2+ and elevations in intracellular Ca2+ concentration ([Ca2+]i) were required for nicotine to increase TH mRNA. The nicotine-elicited rapid rise in [Ca2+]i was inhibited by blockers of either L-type or N-type, and to a lesser extent P/Q-, but not T-type, voltage-gated Ca2+ channels. With continual nicotine treatment, [Ca2+]i… CONTINUE READING

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Distinct effects of omega-toxins and various groups of Ca21-entry inhibitors on nicotinic acetylcholine receptor and Ca21 channels of chromaffin cells

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