Differing roles of CD 18 and VLA-4 in leukocyte migration / activation during anti-GBM nephritis XIA 0 B 0

@inproceedings{Wu2010DifferingRO,
  title={Differing roles of CD 18 and VLA-4 in leukocyte migration / activation during anti-GBM nephritis XIA 0 B 0},
  author={Wu and Anil and Tiwari and Thomas B. Issekutz and James B. Lefkowith},
  year={2010}
}
Differing roles of CD18 and VLA-4 in leukocyte migration/activation during anti-GEM nephritis. The mechanisms underlying leukocyte migration into inflamed glomeruli and their in situ activation are incompletely understood. We addressed this issue by investigating the effects of monoclonal antibodies (mAbs) to CD18 and VLA-4 on these process in the heterologous phase of anti-glomerular basement membrane (GBM) nephritis in rat. Anti-CD 18 mAb substantially attenuated neutrophil (PMN) migration… CONTINUE READING

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