Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.

@article{Sakoda2003DifferingRO,
  title={Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.},
  author={Hideyuki Sakoda and Yukiko Gotoh and Hideki Katagiri and Mineo Kurokawa and Hiraku Ono and Yukiko Onishi and Motonobu Anai and Takehide Ogihara and Midori Fujishiro and Yasushi Fukushima and Miho Abe and Nobuhiro Shojima and Masatoshi Kikuchi and Yoshitomo Oka and Hisamaru Hirai and Tomoichiro Asano},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 28},
  pages={25802-7}
}
Serum- and glucocorticoid-regulated kinase (SGK) is a serine kinase that has a catalytic domain homologous to that of Akt, but lacks the pleckstrin homology domain present in Akt. Akt reportedly plays a key role in various cellular actions, including glucose transport, glycogen synthesis, DNA synthesis, anti-apoptotic activity, and cell proliferation. In this study, we attempted to reveal the different roles of SGK and Akt by overexpressing active mutants of Akt and SGK. We found that… CONTINUE READING

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