Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes

@article{Kishimoto1996DifferingRF,
  title={Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes },
  author={Hidehiro Kishimoto and Zeling Cai and Anders P. Brunmark and Michael R. Jackson and Per A. Peterson and Jonathon Sprent},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={531 - 537}
}
To ensure self tolerance, immature thymocytes with high binding affinity for self peptides linked to major histocompatibility complex (MHC) molecules are eliminated in situ via apoptosis (negative selection). The roles of two costimulatory molecules, B7-1 and intercellular adhesion molecule-1 (ICAM-1), in negative selection was examined by studying apoptosis of T cell receptor transgenic CD4+8+ thymocytes cultured with specific peptides presented by MHC class I-transfected Drosophila cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

An essential role for gp 39 , the ligand for CD 40 , in thymic selection

  • B. J. Fowlkes
  • J . Exp . Med .
  • 1995

Intrathymic and extrathy - nfic clonal deletion ofT cells

  • R. D. Newberry, D. M. Kranz, J. H. Russell
  • Curt . Opin . Immunol .
  • 1995

Adhesion through the LFA - 1 ( CD 11 a / CD 18 ) - ICAM - 1 ( CD 54 ) and the VLA - 4 ( CD 49 d ) - VCAM - 1 ( CD 106 ) pathways prevents apoptosis of germinal center B cells

  • W. Newman, Y. Shimizu
  • 1994

Cross - linking of the TCR - CD 3 complex with CD 4 , CD 8 or LFA - I induces an anti - apoptotic signal in thymocytes : the signal is canceled by FK 506

  • S. Nagata
  • Int . Immunol .
  • 1994

Immunohistochemical analysis of in vivo patterns of Bcl - X expression

  • A. Shabaik, T. Miyashita, H. G. Wang
  • Cancer Res .
  • 1994

Involve - ment of LFA - 1 / intracellular adhesion molecule - l - dependent cell adhesion in CD 40 - mediated inhibition of human B lymphoma cell death induced by surface IgM crosslinking

  • N. Shintaku, D. Hata, K. Katamura, M. Mayumi
  • 1994

Similar Papers

Loading similar papers…