Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

Abstract

Rho family GTPases regulate the cytoskeleton and cell migration and are frequently overexpressed in tumours. Here, we identify two modes of tumour-cell motility in 3D matrices that involve different usage of Rho signalling. Rho signalling through ROCK promotes a rounded bleb-associated mode of motility that does not require pericellular proteolysis. This… (More)
DOI: 10.1038/ncb1019

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Cite this paper

@article{Sahai2003DifferingMO, title={Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis}, author={Erik Sahai and Christopher J. Marshall}, journal={Nature Cell Biology}, year={2003}, volume={5}, pages={711-719} }