Differing activation status and immune effector molecule expression profiles of neonatal and maternal lymphocytes in an African population.

@article{Engelmann2006DifferingAS,
  title={Differing activation status and immune effector molecule expression profiles of neonatal and maternal lymphocytes in an African population.},
  author={Ilka Engelmann and Ulrike Moeller and Andrea Jimena Santamaria and Peter Gottfried Kremsner and Adrian J F Luty},
  journal={Immunology},
  year={2006},
  volume={119 4},
  pages={
          515-21
        }
}
Higher susceptibility of newborns to infections has been attributed to the hypo-responsiveness of their cellular immune system. Here we compared the activation status and expression of cytokines and cytotoxic molecules of cord versus maternal peripheral blood mononuclear cells in an African population. Human leucocyte antigen-DR was expressed on a lower percentage of cord compared to maternal gammadelta and CD3(+) T cells. Similarly, a lower proportion of cord versus maternal gammadelta and CD3… CONTINUE READING