Differing Patterns of Selection and Geospatial Genetic Diversity within Two Leading Plasmodium vivax Candidate Vaccine Antigens

@inproceedings{Parobek2014DifferingPO,
  title={Differing Patterns of Selection and Geospatial Genetic Diversity within Two Leading Plasmodium vivax Candidate Vaccine Antigens},
  author={Christian M Parobek and Jeffrey A. Bailey and Nicholas J. Hathaway and Doung 7 Socheat and William Oscar Rogers and Jonathan J. Juliano},
  booktitle={PLoS neglected tropical diseases},
  year={2014}
}
Although Plasmodium vivax is a leading cause of malaria around the world, only a handful of vivax antigens are being studied for vaccine development. Here, we investigated genetic signatures of selection and geospatial genetic diversity of two leading vivax vaccine antigens--Plasmodium vivax merozoite surface protein 1 (pvmsp-1) and Plasmodium vivax circumsporozoite protein (pvcsp). Using scalable next-generation sequencing, we deep-sequenced amplicons of the 42 kDa region of pvmsp-1 (n = 44… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS