Differentiation therapy of human cancer: basic science and clinical applications.

  title={Differentiation therapy of human cancer: basic science and clinical applications.},
  author={Magdalena Leszczyniecka and Tim Roberts and Paul Dent and Steven Grant and Paul B Fisher},
  journal={Pharmacology & therapeutics},
  volume={90 2-3},
Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic approach to treating this prevalent disease employs agents that modify cancer cell differentiation, termed 'differentiation therapy.' This approach is based on the tacit assumption that many neoplastic cell types exhibit reversible defects in differentiation, which upon appropriate treatment, results in tumor reprogramming and a concomitant loss in proliferative capacity and induction of terminal… CONTINUE READING


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