Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells.

@article{Uddin2004DifferentiationSA,
  title={Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells.},
  author={Shahab Uddin and Jeong Ah-Kang and Jodie Ulaszek and Dolores L Mahmud and Amittha Wickrema},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 1},
  pages={
          147-52
        }
}
p38alpha, p38beta, p38gamma, and p38delta are four isoforms of p38 mitogen-activated protein (MAP) kinase (MAPK) involved in multiple cellular functions such as cell proliferation, differentiation, apoptosis, and inflammation response. In the present study, we examined the mRNA expression pattern of each of the four isoforms during erythroid differentiation of primary erythroid progenitors. We show that p38alpha and p38gamma transcripts are expressed in early hematopoietic progenitors as well… CONTINUE READING
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