Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation.

  title={Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation.},
  author={Grazia Ambrosini and Sharon L Seelman and Gary K. Schwartz},
  journal={Cancer research},
  volume={69 15},
Drg1 was identified as a differentiation-related, putative metastatic suppressor gene in human colon and prostate cancer. Its expression is associated with resistance to irinotecan (CPT-11) therapy in preclinical colorectal cancer models both in vitro and in vivo. However, the functional significance of Drg1 in these processes is unknown. We have shown for the first time that Drg1 directly binds to the BH3-only proapoptotic protein Bim. Depletion of Drg1 by small interfering RNA induced up… CONTINUE READING


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