Differentiation potential of histocompatible parthenogenetic embryonic stem cells.

@article{Lengerke2007DifferentiationPO,
  title={Differentiation potential of histocompatible parthenogenetic embryonic stem cells.},
  author={Claudia Lengerke and Kitai Kim and Paul H. Lerou and George Q. Daley},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1106},
  pages={
          209-18
        }
}
Embryonic stem cells (ESCs) hold unique promise for the development of cell replacement therapies, but derivation of therapeutic products from ESCs is hampered by immunological barriers. Creation of HLA-typed ESC banks, or derivation of customized ESC lines by somatic cell nuclear transfer, have been envisioned for engineering histocompatible ESC-derived products. Proof of principle experiments in the mouse have demonstrated that autologous ESCs can be obtained via nuclear transfer and… CONTINUE READING

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