Differentiation potential of histocompatible parthenogenetic embryonic stem cells.

  title={Differentiation potential of histocompatible parthenogenetic embryonic stem cells.},
  author={Claudia Lengerke and Kitai Kim and Paul H. Lerou and George Q. Daley},
  journal={Annals of the New York Academy of Sciences},
Embryonic stem cells (ESCs) hold unique promise for the development of cell replacement therapies, but derivation of therapeutic products from ESCs is hampered by immunological barriers. Creation of HLA-typed ESC banks, or derivation of customized ESC lines by somatic cell nuclear transfer, have been envisioned for engineering histocompatible ESC-derived products. Proof of principle experiments in the mouse have demonstrated that autologous ESCs can be obtained via nuclear transfer and… CONTINUE READING


Publications citing this paper.
Showing 1-5 of 5 extracted citations

The Immunological Barriers to Regenerative Medicine

Stem Cell Biology and Regenerative Medicine • 2013
View 8 Excerpts
Highly Influenced