Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.

@article{Chang2012DifferentiationOV,
  title={Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.},
  author={Linda J. Chang and Michela Noseda and Michelle Higginson and Michelle Ly and Alexandre Patenaude and Megan Fuller and Alastair Hugh Kyle and Andrew I Minchinton and Mira C Puri and D Ayot Jeoffroy Dumont and Aly Karsan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 18},
  pages={
          6993-8
        }
}
Vascular smooth muscle cells (VSMC) have been suggested to arise from various developmental sources during embryogenesis, depending on the vascular bed. However, evidence also points to a common subpopulation of vascular progenitor cells predisposed to VSMC fate in the embryo. In the present study, we use binary transgenic reporter mice to identify a Tie1(+)CD31(dim)vascular endothelial (VE)-cadherin(-)CD45(-) precursor that gives rise to VSMC in vivo in all vascular beds examined. This… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation

FA High
  • J Clin Invest
  • 2007
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 1 EXCERPT

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