Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

@article{Gregori2010DifferentiationOT,
  title={Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.},
  author={Silvia Gregori and Daniela Tomasoni and Valentina Pacciani and Miriam Scirpoli and Manuela Battaglia and Chiara Francesca Magnani and Ehud Hauben and Maria Grazia Roncarolo},
  journal={Blood},
  year={2010},
  volume={116 6},
  pages={935-44}
}
Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identified and characterized a subset of IL-10-producing human dendritic cells (DCs), termed DC-10, which are present in vivo and can be induced in vitro in the presence of IL-10. DC-10… CONTINUE READING
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