Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia.

@article{Thomas1994DifferentiationOT,
  title={Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia.},
  author={Teresa Thomas and B K Elnazir and Janice M. Marshall},
  journal={Experimental physiology},
  year={1994},
  volume={79 5},
  pages={809-22}
}
In two groups of Saffan-anaesthetized, spontaneously breathing rats we have attempted to identify the peripheral influences of adenosine in mediating the responses evoked by hypoxia by using an adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT, 20 mg kg-1 i.v., Group 1) and adenosine deaminase (ADA, 500 units in 0.04 ml infused into the tail artery for 10 min, Group 2); neither of these drugs crosses the blood-brain barrier. Recordings were made of respiration, heart rate… CONTINUE READING

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