Differentiation of the mammary gland and susceptibility to carcinogenesis

@article{Russo2005DifferentiationOT,
  title={Differentiation of the mammary gland and susceptibility to carcinogenesis},
  author={Jos{\'e} Russo and Lee K. Tay and Irma H. Russo},
  journal={Breast Cancer Research and Treatment},
  year={2005},
  volume={2},
  pages={5-73}
}
SummaryIt has been demonstrated that in humans certain factors such as early menarche, late pregnancy, and nulliparity are associated with a higher risk of developing breast cancer, while early pregnancy acts as a protective factor. Induction of mammary cancer in rats by administration of the chemical carcinogen 7, 12-dimethylbenz(a)anthracene reveals that the same factors influencing human breast cancer risk also affect the susceptibility of the rat mammary gland to the chemical carcinogen… 

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  • Biology
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  • 2006
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It was concluded that treatment of virgin rats with the hormone combination norethynodrel-mestranol resulted in long lasting structural changes in the mammary gland which protected this organ from a subsequent carcinogenic insult.

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  • Biology, Medicine
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It is still unclear whether estrogens arecarcinogenicity of estrogens to the human breast, but in experimental animal models estrogens can induce mammary cancer.
...

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