Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope.

@article{Sun1976DifferentiationOT,
  title={Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope.},
  author={T T Sun and Howard Green},
  journal={Cell},
  year={1976},
  volume={9 4 Pt 1},
  pages={511-21}
}
Human epidermal keratinocytes grow from single cells into stratified colonies. Cells in the upper layers of the colonies lose their ability to divide and begin terminal differentiation. In this process, there develops a cornified cell envelope that remains insoluble after heating in solutions of sodium dodecylsulfate and beta-mercaptoethanol. The insolubility of the cornified envelope depends upon proteins, since after treatment with proteolytic enzymes, the envelope becomes soluble in the… CONTINUE READING
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