Differentiation of smooth muscle progenitor cells in peripheral blood and its application in tissue engineered blood vessels

@article{Xie2008DifferentiationOS,
  title={Differentiation of smooth muscle progenitor cells in peripheral blood and its application in tissue engineered blood vessels},
  author={Shang-zhe Xie and Ning-tao Fang and Shui Liu and Ping Zhou and Yi Zhang and Song-mei Wang and Hong-yang Gao and Luan-feng Pan},
  journal={Journal of Zhejiang University SCIENCE B},
  year={2008},
  volume={9},
  pages={923-930}
}
A major shortcoming in tissue engineered blood vessels (TEBVs) is the lack of healthy and easily attainable smooth muscle cells (SMCs). Smooth muscle progenitor cells (SPCs), especially from peripheral blood, may offer an alternative cell source for tissue engineering involving a less invasive harvesting technique. SPCs were isolated from 5-ml fresh rat peripheral blood by density-gradient centrifugation and cultured for 3 weeks in endothelial growth medium-2-MV (EGM-2-MV) medium containing… CONTINUE READING

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