Differentiation of reinfection from relapse in recurrent Lyme disease.

  title={Differentiation of reinfection from relapse in recurrent Lyme disease.},
  author={Robert B. Nadelman and Kl{\'a}ra Hanincov{\'a} and Priyanka Mukherjee and Dionysios Liveris and John Nowakowski and Donna McKenna and Dustin Brisson and Denise L. Cooper and Susan Bittker and Gul Madison and Diane Holmgren and I. Schwartz and Gary P. Wormser},
  journal={The New England journal of medicine},
  volume={367 20},
BACKGROUND Erythema migrans is the most common manifestation of Lyme disease. Recurrences are not uncommon, and although they are usually attributed to reinfection rather than relapse of the original infection, this remains somewhat controversial. We used molecular typing of Borrelia burgdorferi isolates obtained from patients with culture-confirmed episodes of erythema migrans to distinguish between relapse and reinfection. METHODS We determined the genotype of the gene encoding outer… CONTINUE READING
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