Differentiation of regulatory Foxp3+ T cells in the thymic cortex.

@article{Liston2008DifferentiationOR,
  title={Differentiation of regulatory Foxp3+ T cells in the thymic cortex.},
  author={Adrian Liston and Katherine M Nutsch and Andrew G. Farr and Jennifer M Lund and Jeffery P Rasmussen and Pandelakis A Koni and Alexander Yu Rudensky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 33},
  pages={
          11903-8
        }
}
Regulatory Foxp3(+) T cells (T(R)) are indispensable for preventing autoimmune pathology in multiple organs and tissues. During thymic differentiation T cell receptor (TCR)-ligand interactions within a certain increased affinity range, in conjunction with gammac-containing cytokine receptor signals, induce Foxp3 expression and thereby commit developing thymocytes to the T(R) lineage. The contribution of distinct MHC class II-expressing accessory cell types to the differentiation process of… CONTINUE READING

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