Differentiation of regenerating pancreatic cells into hepatocyte-like cells.

  title={Differentiation of regenerating pancreatic cells into hepatocyte-like cells.},
  author={Dante G. Scarpelli and M. Sambasiva Rao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={78 4},
Differentiation is the process by which multicellular organisms achieve the specialized functions necessary for adaptation and survival. An in vivo model in the Syrian golden hamster is described in which regenerating pancreatic cells are converted into hepatocyte-like cells, as evidenced by the presence of albumin, peroxisomes, and a variety of morphological markers. These cells are stable after the conversion is triggered by a single dose of the carcinogen N-nitrosobis(2-oxopropyl)amine… CONTINUE READING