Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion.

@article{Watanabe2002DifferentiationOP,
  title={Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion.},
  author={Masahiko Watanabe and Yoshiaki Toyama and Akiko Nishiyama},
  journal={Journal of neuroscience research},
  year={2002},
  volume={69 6},
  pages={826-36}
}
Cells that express the NG2 proteoglycan (NG2+ cells) constitute a large cell population in the adult mammalian central nervous system (CNS). They give rise to mature oligodendrocytes in culture and are thus considered to be oligodendrocyte progenitor cells (OPCs). They proliferate in response to a variety of insults to the CNS, but their ability to differentiate into oligodendrocytes in vivo has not been established. We used bromodeoxyuridine (BrdU) to trace the fate of NG2+ cells that… CONTINUE READING

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