Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency.

@article{Leng2015DifferentiationOP,
  title={Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency.},
  author={Lizhi Leng and Yueqiu Tan and Fei Gong and Liang Hu and Qi Ouyang and Yan Zhao and Guang-xiu Lu and Ge Lin},
  journal={Human reproduction},
  year={2015},
  volume={30 3},
  pages={737-48}
}
STUDY QUESTION Can the induced pluripotent stem cells (iPSCs) derived from women with primary ovarian insufficiency (POI) differentiate into germ cells for potential disease modeling in vitro? SUMMARY ANSWER The iPSC lines derived from POI patients with 46, X, del(X)(q26) or 46, X, del(X)(q26)9qh+ could differentiate into germ cells and expressed lower levels of genes in the deletion region of the X chromosome. WHAT IS KNOWN ALREADY iPSC technology has been envisioned as an approach for… CONTINUE READING
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