Differentiation of pluripotent embryonic stem cells into cardiomyocytes.

  title={Differentiation of pluripotent embryonic stem cells into cardiomyocytes.},
  author={Kenneth R. Boheler and Jaroslaw Czyz and David Tweedie and Huang-Tian Yang and Sergey V. Anisimov and Anna M. Wobus},
  journal={Circulation research},
  volume={91 3},
Embryonic stem (ES) cells have been established as permanent lines of undifferentiated pluripotent cells from early mouse embryos. ES cells provide a unique system for the genetic manipulation and the creation of knockout strains of mice through gene targeting. By cultivation in vitro as 3D aggregates called embryoid bodies, ES cells can differentiate into derivatives of all 3 primary germ layers, including cardiomyocytes. Protocols for the in vitro differentiation of ES cells into… CONTINUE READING
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Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation

  • AM Wobus, K Guan, Yang H-T, KR Boheler
  • Methods Mol Biol
  • 2002

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