Differentiation of pancreatic acinar cells into duct-like cells in vitro.

  title={Differentiation of pancreatic acinar cells into duct-like cells in vitro.},
  author={Ariel E. Arias and Mo{\"i}se Bendayan},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={69 5},
BACKGROUND Previous studies have shown that a combination of both the extracellular matrix and secretagogues plays critical roles in the maintenance of well-differentiated pancreatic acinar cells in culture. In the present study, we have shown that, upon proper stimulation, acinar cells change their growth pattern and morphologic appearance to a duct like phenotype. EXPERIMENTAL DESIGN Both rat and guinea pig acinar cells were cultured on or embedded into the Matrigel basement membrane, in… CONTINUE READING


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