Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms

@article{Parasassi2005DifferentiationON,
  title={Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms},
  author={Tiziana Parasassi and Roberto Brunelli and Luisa Bracci-Laudiero and Giulia Greco and Anna C Gustafsson and Eva K Krasnowska and Joakim Lundeberg and Thomas Lundeberg and Eugenia Pittaluga and Maria C Romano and Annalucia Serafino},
  journal={Cell Death and Differentiation},
  year={2005},
  volume={12},
  pages={1285-1296}
}
We examined the morphological, biochemical and molecular outcome of a nonspecific sulfhydryl reduction in cells, obtained by supplementation of N-acetyl-L-cysteine (NAC) in a 0.1–10 mM concentration range. In human normal primary keratinocytes and in colon and ovary carcinoma cells we obtained evidences for: (i) a dose-dependent inhibition of proliferation without toxicity or apoptosis; (ii) a transition from a proliferative mesenchymal morphology to cell-specific differentiated structures… CONTINUE READING

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