Differentiation of neurospheres from the enteric nervous system

  title={Differentiation of neurospheres from the enteric nervous system},
  author={K H Sch{\"a}fer and Cornelia Irene Hagl and Ulrich Rauch},
  journal={Pediatric Surgery International},
The enteric nervous system (ENS) derives from neural crest cells, which migrate from the neural tube into the developing gut. The neuronal and glial precursor cells migrate mainly from the oral towards the anal end of the gastrointestinal tract. So far, knowledge about the multipotent influences upon the ENS development, especially its neurotrophic support, derives mainly from knock-out models. The in vitro technique of isolating enteric neuronal precursor cells allows to study the effects of… CONTINUE READING
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