Differentiation of mononuclear precursors into osteoclasts on the surface of Si-substituted hydroxyapatite.

@article{Botelho2006DifferentiationOM,
  title={Differentiation of mononuclear precursors into osteoclasts on the surface of Si-substituted hydroxyapatite.},
  author={Claudia Manuela Botelho and Roger A. Brooks and G. Spence and I. McFarlane and Maria Ascens{\~a}o Lopes and Serena M. Best and Jos{\'e} Domingos Santos and Neil Rushton and William Bonfield},
  journal={Journal of biomedical materials research. Part A},
  year={2006},
  volume={78 4},
  pages={709-20}
}
In healthy bone, resorption and synthesis are in perfect coordination. In previous studies we demonstrated that the incorporation of silicon into the hydroxyapatite (HA) lattice enhances the proliferation and differentiation of human osteoblasts. Therefore, the aim of this study was to demonstrate the effect of silicon-substituted HA (0.8 and 1.5 wt % Si-HA… CONTINUE READING