Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.

@article{Randolph1998DifferentiationOM,
  title={Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.},
  author={Gwendalyn J Randolph and Sylvie Beaulieu and Serge J. Lebecque and Ralph Marvin Steinman and William A Muller},
  journal={Science},
  year={1998},
  volume={282 5388},
  pages={480-3}
}
Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal… CONTINUE READING
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