Differentiation of human neuroblastoma cells in vitro--morphological changes induced by dibutyrl cyclic AMP.

@article{Ishikawa1977DifferentiationOH,
  title={Differentiation of human neuroblastoma cells in vitro--morphological changes induced by dibutyrl cyclic AMP.},
  author={Satoko Ishikawa},
  journal={Acta pathologica japonica},
  year={1977},
  volume={27 5},
  pages={697-711}
}
Differentiation ability of neuroblastoma cells was studied in vitro, light and electron microscopically using three continuously cultured cell lines (NB-1, GOTO, and YT-nu) of human origin. The cells ordinarily cultured appeared to differentiate along directions of both ganglionic and paraganglionic characterized by cytoplasmic catecholamine granules measuring 150 to 250 treatment with But2cAMP in NB-1 and YT-nu cells, but GOTO cells revealed only one-directed differentiation along ganglionic… CONTINUE READING