Differentiation of human monoblastic leukemia U937 cells induced by inhibitors of myosin light chain kinase and prevention of differentiation by granulocyte-macrophage colony-stimulating factor.

@article{Makishima1993DifferentiationOH,
  title={Differentiation of human monoblastic leukemia U937 cells induced by inhibitors of myosin light chain kinase and prevention of differentiation by granulocyte-macrophage colony-stimulating factor.},
  author={Makoto Makishima and Yoshio Honma and Motoo Hozumi and Nanae Nagata and Kazuo Motoyoshi},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1176 3},
  pages={245-9}
}
Inhibitors of protein kinase activities are useful for the study of intracellular signal transduction and some of these inhibitors are reported to induce differentiation of human leukemia cells. We examined effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with several kinase inhibitors on differentiation of human leukemia… CONTINUE READING