Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci.

@article{Brtov2008DifferentiationOH,
  title={Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci.},
  author={Eva B{\'a}rtov{\'a} and Jana Krejc{\'i} and Andrea Harni{\vc}arov{\'a} and Stanislav Kozubek},
  journal={Differentiation; research in biological diversity},
  year={2008},
  volume={76 1},
  pages={24-32}
}
Human embryonic stem cells (hES) are unique in their pluripotency and capacity for self-renewal. Therefore, we have studied the differences in the level of chromatin condensation in pluripotent and all-trans retinoic acid-differentiated hES cells. Nuclear patterns of the Oct4 (6p21.33) gene, responsible for hES cell pluripotency, the C-myc (8q24.21) gene, which controls cell cycle progression, and HP1 protein (heterochromatin protein 1) were investigated in these cells. Unlike differentiated… CONTINUE READING

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