Differentiation of human ES cell-derived neural progenitors to neuronal cells with regional specific identity by co-culturing of notochord and somite.

@article{Salehi2012DifferentiationOH,
  title={Differentiation of human ES cell-derived neural progenitors to neuronal cells with regional specific identity by co-culturing of notochord and somite.},
  author={Hossein Salehi and Khadijeh Karbalaie and Ahmad Salamian and Abbas Kiani and Shahnaz Razavi Razavi and Mohammad Hossein Nasr-esfahani and Hossein Baharvand},
  journal={Stem cell research},
  year={2012},
  volume={8 1},
  pages={
          120-33
        }
}
Limitations to the in vivo study of human nervous system development make it necessary to design an in vitro model to evaluate the in vivo effects of surrounding tissues on neurogenesis and regional identity of the human neural plate. Rostral neural progenitors (NPs) were initially generated from adherent human embryonic stem cells (hESCs) in a defined condition and characterized. Then, to find the role of somites (S) and notochords (N) in rostro-caudal (RC) and dorso-ventral (DV) patterning of… CONTINUE READING
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