Differentiation of highly prevalent IS6110 single-copy strains of Mycobacterium tuberculosis from a rural community in South India with an ongoing DOTS programme.

@article{Das2005DifferentiationOH,
  title={Differentiation of highly prevalent IS6110 single-copy strains of Mycobacterium tuberculosis from a rural community in South India with an ongoing DOTS programme.},
  author={Sulochana D. Das and Sujatha Narayanan and Lalitha Hari and Sugeerappa Laxmanappa Hoti and Ramasamy Thangathurai and Niruparani Charles and K. Jaggarajamma and P. R. Narayanan},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2005},
  volume={5 1},
  pages={67-77}
}
We have prospectively analysed the DNA fingerprinting of Mycobacterium tuberculosis strains in a rural community from high prevalence area in South India with an ongoing DOTS programme. Strains from 451 culture-positive cases, diagnosed during July 1999-December 2000, were fingerprinted initially by both IS6110 and DR probes followed by polymorphic GC-rich repeat sequences (PGRS) typing only on low-copy strains. The results were correlated with selected epidemiological and clinical data. Forty… CONTINUE READING

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