Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats.

@article{Zhan2006DifferentiationOH,
  title={Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats.},
  author={Yuan Zhan and Y Wang and Lin Heng Wei and Harvey Shi-Hsien Chen and Xiuli Cong and Ran Fei and Y Gao and Fengen Liu},
  journal={Transplantation proceedings},
  year={2006},
  volume={38 9},
  pages={3082-5}
}
It has been reported that hematopoietic stem cells (HSC) can differentiate into hepatocytes in the normal liver and in some pathologic environments. The aim of this study was to investigate whether HSC can differentiate into hepatocytes in cases of established liver fibrosis. Rat liver fibrosis was induced by subcutaneous injection of tetrachloride (CCl4). Thy+ CD3- CD45RA- HSC in bone marrow cells, which had been enriched by fluorescence-activated cell sorting (FACS), were labeled with PKH26… CONTINUE READING
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