Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

@inproceedings{Krutler2017DifferentiationOG,
  title={Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells},
  author={Nike J Kr{\"a}utler and Dan Suan and Danyal Butt and Katherine Bourne and Jana R Hermes and Tyani D Chan and Christopher Sundling and Warren Kaplan and Peter Schofield and Jennifer Jackson and Antony Basten and Daniel Christ and Robert Brink},
  booktitle={The Journal of experimental medicine},
  year={2017}
}
Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of the GC… CONTINUE READING

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