Differentiation of chondrocytes and scleroblasts during dorsal fin skeletogenesis in flounder larvae

  title={Differentiation of chondrocytes and scleroblasts during dorsal fin skeletogenesis in flounder larvae},
  author={Tohru Suzuki and Yutaka Haga and Toshio Takeuchi and Susumu Uji and Hisashi Hashimoto and Tadahide Kurokawa},
In teleosts, the embryonic fin fold consists of a peridermis, an underlying epidermis and a small number of mesenchymal cells. Beginning from such a simple structure, the fin skeletons, including the proximal and distal radials and lepidotrichia (finrays), develop in the dorsal fin fold at the larval stage. Their process of skeletogenesis and embryonic origin are unclear. Using flounder larvae, we report the differentiation process for chondrocytes and scleroblasts prior to fin skeletogenesis… 

Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo‐devo perspective

The process of formation and subsequent fusion of the caudalmost vertebral bodies in zebrafish, where fusion is a normal process, is explored, to reveal whether the product of fusion is on an evolutionary or a developmental scale.

The teleost intervertebral region acts as a growth center of the centrum: In vivo visualization of osteoblasts and their progenitors in transgenic fish

  • K. InohayaY. TakanoA. Kudo
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2007
In vivo bone labeling in fact confirmed active matrix formation and mineralization of the perichordal centrum exclusively in the intervertebral region of zebrafish larvae as well as medaka larvae, suggesting that the teleost interverTEbral region acts as a growth center of theperichordAL centrum, where the sclerotome‐derived cells differentiate into osteoblasts.

Zebrafish Fins as a Model System for Skeletal Human Studies

A general conclusion of this study states that lepidotrichia is a special skeletal tissue different to cartilage, bone, enamel, or dentine in fishes, according to its extracellular matrix (ECM) composition.

Evx1 is required for joint formation in zebrafish fin dermoskeleton

It is found that Evx1 is not required for either fin outgrowth or regeneration, and all of the fins form normally in evx1 mutants, and there are no significant changes in fin length.

Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish

The results suggest that Hedgehog proteins can regulate skeletal appendage outgrowth independent of a ZPA and demonstrates an unexpected mechanism for mediating Shh signals in a median fin primordium.

Excess Retinoic Acid Induces Fusion of Centra by Degenerating Intervertebral Ligament Cells in Japanese flounder, Paralichthys olivaceus.

It is concluded that RA initially damages the intervertebral ligaments, and these defects lead to fusion, narrowing of centra, and loss of intervertertebral joints in the vertebral column.

Retracted: Evolution and development of the homocercal caudal fin in teleosts

A scenario for acquisition and morphogenesis of the homocercal caudal skeleton during vertebrate evolution is proposed by comparing developmental processes in various vertebrates.



An analysis of in vivo cell migration during teleost fin morphogenesis.

The migration of the mesenchymal cells between 135 and 220 h of development is investigated using Nomarski interference contrast microscopy and time-lapse video recording, which revealed that, generally, aligned processes were in close association with the surface of the actinotrichial fibrils and not the spaces between them.

Trunk neural crest origin of caudal fin mesenchyme in the zebrafish Brachydanio rerio

It is suggested that a causal link between neural crest-derived mesenchyme and the development of the exoskeleton has been evolutionary conserved throughout the neural crest of teleosts but has been lost in the trunk crest of higher vertebrates.

Segment and cell type lineage restrictions during pharyngeal arch development in the zebrafish embryo.

It is suggested that arch precursors may be specified as to their eventual fates before the major morphogenetic movements that form the arch primordia, as in the fashion of vertebrate rhombomeres or segmental lineage compartments in Drosophila.

Modulation of epidermal cell shaping and extracellular matrix during caudal fin morphogenesis in the zebra fish Brachydanio rerio.

During early stages of fold production a temporary set of previously unreported extracellular cross fibres spans the subepidermal space at right angles to actinotrichia, which could be advantageous for maintaining the structural integrity of the early fin fold.

Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays.

A role for shh, ptc1 and bmp2 in patterning of the dermoskeleton of developing and regenerating teleost fins is suggested.

Genetic analysis of fin formation in the zebrafish, Danio rerio.

In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during embryogenesis, and in mutants of one of these genes, dackel (dak), pECToral fin buds form initially, but later the fin epithelium fails to expand.

Roles for Fgf signaling during zebrafish fin regeneration.

It is found that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation and in distal blastemal tissue during regenerative outgrowth and that a specific inhibitor of Fgfr1 applied immediately following fin amputation blocks Blastema formation, without obvious effects on wound healing.

Relationships between cellular condensation, preosteoblast formation and epithelial-mesenchymal interactions in initiation of osteogenesis.

The finding that the osteogenic condensation in the Mandibular arch is a major branch of a common condensation that provides osteogenic mesenchyme to both maxillary and mandibular arches establishes a closer link between mechanisms controlling development of the skeleton in these two arches than previously suspected.

Induction of the prospective neural crest of Xenopus.

It is suggested that the prospective neural crest is induced in normal embryos in the ectoderm that overlies the junction of the domains that express noggin and Xwnt-8 and not NCAM although the mesoderm marker Xbra is also expressed.

Caudal fin regeneration in wild type and long-fin mutant zebrafish is affected by retinoic acid.

It is shown that the regenerating caudal fin is sensitive to RA-treatment, and clear teratogenic effects on the dorso-ventral axis are observed under many of the experimental conditions investigated both in wild type and long-fin mutants.