Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity.

@article{Floryk2005DifferentiationOA,
  title={Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity.},
  author={Daniel Floryk and Eliezer Huberman},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={
          11588-96
        }
}
Recently, we have reported that inosine 5'-monophosphate dehydrogenase inhibitors, such as mycophenolic acid (MPA), induce the differentiation of PC-3 cells, which are derived from a human androgen-independent prostate cancer, into cells with a phenotype resembling maturing prostate secretory cells. Here, we describe such differentiation induced by the histone deacetylase inhibitor tributyrin. The maturation was defined by cytoplasmic vacuole production and induction of CD10, CD46, CD55, GRP78… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Butyrate and phenylacetate as differentiating agents: practical problems and opportunities.

  • Journal of cellular biochemistry. Supplement
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Nuclear factor-nB: the enemy within

BB Aggarwal
  • Cancer Cell 2004;6:203–8
  • 2004
VIEW 1 EXCERPT