Differentiation of Tr 1 cells by immature dendritic cells requires IL-10 but not CD 25 CD 4 Tr cells

@inproceedings{Levings2005DifferentiationOT,
  title={Differentiation of Tr 1 cells by immature dendritic cells requires IL-10 but not CD 25 CD 4 Tr cells},
  author={Megan K Levings and Silvia Gregori and Eleonora Tresoldi and Sabrina Cazzaniga and Chiara Bonini and Maria Grazia Roncarolo},
  year={2005}
}
Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is not only to sense danger but also to tolerize the immune system to antigens encountered in the absence of maturation/inflammatory stimuli. Indeed, if a naive T cell encounters its antigen on immature DCs (iDCs), it may differentiate into a T-regulatory (Tr) rather than a T-effector cell. However, little is known about the mechanisms by which iDCs… CONTINUE READING

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