Differentiation of Multipotent Vascular Stem Cells Contributes to Vascular Diseases

  title={Differentiation of Multipotent Vascular Stem Cells Contributes to Vascular Diseases},
  author={Zhenyu Tang and Aijun Wang and Falei Yuan and Zhiqiang Yan and Bo Liu and Julia S F Chu and J A Helms and Song Li},
  booktitle={Nature communications},
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases. Here we provide evidence that challenges this theory. We identify a new type of stem cell in the blood vessel wall, named multipotent vascular stem cells. Multipotent vascular stem cells express markers, including Sox17, Sox10 and S100β, are cloneable, have telomerase activity, and can… CONTINUE READING
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