Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.

@article{Mercer2014DifferentiationOI,
  title={Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.},
  author={Frances Mercer and Alka Khaitan and Lina Kozhaya and Judith A. Aberg and Derya Unutmaz},
  journal={Journal of immunology},
  year={2014},
  volume={193 3},
  pages={1047-54}
}
A subset of human regulatory T cells (Tregs) secretes IL-17 and thus resembles Th17 effector cells. How IL-17(+) Tregs differentiate from naive precursors remains unclear. In this study, we show that IL-17-producing T cells can differentiate from CCR6(+) naive T cell precursors in the presence of IL-2, IL-1β, TGF-β, and IL-23. CCR6(+) naive T cells are present in adult peripheral and umbilical cord blood and in both conventional T naive and FOXP3(+) naive Treg subsets. IL-17(+) cells derived… CONTINUE READING