Differentiation markers (S-100, GFAP, NSE and D2) in fetal rat brain cells during malignant transformation in cell culture

@article{Laerum1985DifferentiationM,
  title={Differentiation markers (S-100, GFAP, NSE and D2) in fetal rat brain cells during malignant transformation in cell culture},
  author={Ole Didrik Laerum and Sverre Jarl M\ork and {\AA}. Haugen and Elisabeth Bock and Lars E. Rosengren and Kenneth H. Haglid},
  journal={Journal of Neuro-Oncology},
  year={1985},
  volume={3},
  pages={137-146}
}
Malignant cell lines obtained by ethyl nitrosourea (EtNU)-induced transformation of fetal rat brain cells in culture express protein markers of different types of neural cells. These are the nervous system-characteristic S-100 protein; glial fibrillary acidic protein (GFAP); neuron-specific-enolase (NSE), and the D2-cell adhesion molecule. S-100 protein was absent in fetal brain cells in culture, but gradually appeared in the later stages of malignant transformation and further increased at… CONTINUE READING