Differentiation inhibiting activity (DIA/LIF) and mouse development.


Analysis of the differentiation in culture of murine embryonic stem (ES) cells has resulted in the identification and characterization of the regulatory factor differentiation inhibiting activity (DIA). DIA specifically suppresses differentiation of the pluripotential ES cells without compromise of their developmental potential. DIA is identical to the… (More)


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@article{Smith1992DifferentiationIA, title={Differentiation inhibiting activity (DIA/LIF) and mouse development.}, author={A. G. Smith and Jeanne Nichols and M. Robertson and Peter David Rathjen}, journal={Developmental biology}, year={1992}, volume={151 2}, pages={339-51} }