Differentiation induction as a treatment for hematologic malignancies

@article{Miller2002DifferentiationIA,
  title={Differentiation induction as a treatment for hematologic malignancies},
  author={Wilson H. Miller and Samuel Waxman},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={3496-3506}
}
In many acute leukemias and some lymphomas, aberrant di€erentiation is a major feature of the malignant phenotype that often results from a single genetic alteration and hence provides a site-speci®c target for therapy (Look, 1997). The oncogenic event frequently leads to the generation of a fusion gene that facilitates proliferation by inhibiting a tumor suppressor gene and also disrupts signaling pathways required for di€erentiation (Melnick and Licht, 1999). In many cell lines and primary… CONTINUE READING

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