Differentiation-inducing therapy for solid tumors.

  title={Differentiation-inducing therapy for solid tumors.},
  author={Hitoshi Kawamata and Masatsugu Tachibana and Takahiro Fujimori and Yutaka Imai},
  journal={Current pharmaceutical design},
  volume={12 3},
Treating malignant tumor through the induction of cell differentiation has been an attractive concept, but clinical development of differentiation-inducing agents to treat malignant tumor, especially for solid tumors has been limited to date. Nerve growth factor, all trans retinoic acid, dimethyl sulfoxide, active form vitamin D(3), peroxisome proliferator-activated receptorgamma, 12-0-tetradecanoylphorbol 13-acetate, hexamethylene-bis-acetamide, transforming growth factor-beta, butyric acid… CONTINUE READING


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